Skip to main page content
U.S. flag

An official website of the United States government

Dot gov

The .gov means it’s official.
Federal government websites often end in .gov or .mil. Before sharing sensitive information, make sure you’re on a federal government site.

Https

The site is secure.
The https:// ensures that you are connecting to the official website and that any information you provide is encrypted and transmitted securely.

Access keys NCBI Homepage MyNCBI Homepage Main Content Main Navigation

Search Page

Filters

My NCBI Filters

Results by year

Table representation of search results timeline featuring number of search results per year.

Year Number of Results
2001 12
2002 16
2003 19
2004 24
2005 24
2006 18
2007 30
2008 27
2009 37
2010 42
2011 34
2012 31
2013 42
2014 50
2015 44
2016 52
2017 32
2018 27
2019 29
2020 43
2021 29
2022 21
2023 18
2024 9

Text availability

Article attribute

Article type

Publication date

Search Results

641 results

Results by year

Citations

6 articles found by citation matching
Show all

Search results

Filters applied: . Clear all
Page 1
FBXL12 degrades FANCD2 to regulate replication recovery and promote cancer cell survival under conditions of replication stress.
Brunner A, Li Q, Fisicaro S, Kourtesakis A, Viiliäinen J, Johansson HJ, Pandey V, Mayank AK, Lehtiö J, Wohlschlegel JA, Spruck C, Rantala JK, Orre LM, Sangfelt O. Brunner A, et al. Mol Cell. 2023 Oct 19;83(20):3720-3739.e8. doi: 10.1016/j.molcel.2023.07.026. Epub 2023 Aug 16. Mol Cell. 2023. PMID: 37591242 Free article.
Fanconi anemia (FA) signaling, a key genomic maintenance pathway, is activated in response to replication stress. Here, we report that phosphorylation of the pivotal pathway protein FANCD2 by CHK1 triggers its FBXL12-dependent proteasomal degradation, facilit …
Fanconi anemia (FA) signaling, a key genomic maintenance pathway, is activated in response to replication stress. Here, we rep …
Severe Fanconi Anemia phenotypes in Fancd2 depletion mice.
Yang Q, Xie H, Zhong Y, Li D, Ke X, Ying H, Yu B, Zhang T. Yang Q, et al. Biochem Biophys Res Commun. 2019 Jun 30;514(3):713-719. doi: 10.1016/j.bbrc.2019.04.201. Epub 2019 May 9. Biochem Biophys Res Commun. 2019. PMID: 31078270
Fanconi anemia (FA) is a genetic disorder characterized by congenital malfunction, bone marrow failure and hypersensitivity to DNA damage. FANCD2 protein play the central role in FA pathway. To study the in vivo role of FANCD2, we generated and charact …
Fanconi anemia (FA) is a genetic disorder characterized by congenital malfunction, bone marrow failure and hypersensitivity to …
Pan-cancer analysis of the tumorigenic role of Fanconi anemia complementation group D2 (FANCD2) in human tumors.
Xie X, Zhao Y, Du F, Cai B, Fang Z, Liu Y, Sang Y, Ma C, Liu Z, Yu X, Zhang C, Jiang J, Gao Z, Liu Y, Lin X, Jing H, Zhong X, Cong L, Dai H, Sha D, Shao N, Feng H, Li L, Liu J, Shang L. Xie X, et al. Genomics. 2024 Jan;116(1):110762. doi: 10.1016/j.ygeno.2023.110762. Epub 2023 Dec 15. Genomics. 2024. PMID: 38104669 Free article.
Monoubiquitination of FANCD2 is a central step in the activation of the Fanconi anemia (FA) pathway after DNA damage. ...At present, few studies have investigated FANCD2 in tumors, and no pan-cancer research on FANCD2 has been conducted. ...
Monoubiquitination of FANCD2 is a central step in the activation of the Fanconi anemia (FA) pathway after DNA damage. . …
Phosphorylation by ATR triggers FANCD2 chromatin loading and activates the Fanconi anemia pathway.
Kupculak M, Bai F, Luo Q, Yoshikawa Y, Lopez-Martinez D, Xu H, Uphoff S, Cohn MA. Kupculak M, et al. Cell Rep. 2023 Jul 25;42(7):112721. doi: 10.1016/j.celrep.2023.112721. Epub 2023 Jun 30. Cell Rep. 2023. PMID: 37392383 Free PMC article.
The Fanconi anemia (FA) pathway repairs DNA interstrand crosslinks (ICLs) in humans. ...Taken together, we describe a mechanism where ATR triggers FANCD2/FANCI loading onto chromosomes....
The Fanconi anemia (FA) pathway repairs DNA interstrand crosslinks (ICLs) in humans. ...Taken together, we describe a mechanis …
Fanconi anemia complementation group D2 promotes sensitivity of endometrial cancer cells to chemotherapeutic agents by inhibiting the ferroptosis pathway.
Lin HH, Zeng WH, Yang HK, Huang LS, Pan R, Lei NX. Lin HH, et al. BMC Womens Health. 2024 Jan 13;24(1):41. doi: 10.1186/s12905-023-02857-4. BMC Womens Health. 2024. PMID: 38218826 Free PMC article.
BACKGROUND: Resistance can develop during treatment of advanced endometrial cancer (EC), leading to unsatisfactory results. Fanconi anemia complementation group D2 (Fancd2) has been shown to be closely related to drug resistance in cancer …
BACKGROUND: Resistance can develop during treatment of advanced endometrial cancer (EC), leading to unsatisfactory results. Fanconi …
Fanconi anemia-associated chromosomal radial formation is dependent on POLteta-mediated alternative end joining.
Rogers CB, Kram RE, Lin K, Myers CL, Sobeck A, Hendrickson EA, Bielinsky AK. Rogers CB, et al. Cell Rep. 2023 May 30;42(5):112428. doi: 10.1016/j.celrep.2023.112428. Epub 2023 Apr 21. Cell Rep. 2023. PMID: 37086407 Free PMC article.
Activation of the Fanconi anemia (FA) pathway after treatment with mitomycin C (MMC) is essential for preventing chromosome translocations termed "radials." ...Furthermore, treatment of FANCD2(-/-) cells with POLteta inhibitors abolishes radials and leads to …
Activation of the Fanconi anemia (FA) pathway after treatment with mitomycin C (MMC) is essential for preventing chromosome tr …
FANCD2 and DNA Damage.
Nepal M, Che R, Ma C, Zhang J, Fei P. Nepal M, et al. Int J Mol Sci. 2017 Aug 19;18(8):1804. doi: 10.3390/ijms18081804. Int J Mol Sci. 2017. PMID: 28825622 Free PMC article. Review.
Investigators have dedicated considerable effort to understanding the molecular basis underlying Fanconi Anemia (FA), a rare human genetic disease featuring an extremely high incidence of cancer and many congenital defects. Among those studies, FA group D2 …
Investigators have dedicated considerable effort to understanding the molecular basis underlying Fanconi Anemia (FA), a rare h …
Malignant Transformation of Fanconi Anemia Complementation Group D2-deficient (Fancd2 (-/-)) Hematopoietic Progenitor Cells by a Single HPV16 Oncogene.
Zhang X, Fisher R, Shields D, Hou W, Franicola D, Wang H, Epperly MW, Rigatti L, Greenberger JS. Zhang X, et al. In Vivo. 2019 Mar-Apr;33(2):303-311. doi: 10.21873/invivo.11476. In Vivo. 2019. PMID: 30804107 Free PMC article.
AIM: To demonstrate that Fanconi anemia complementation group D2-deficient (Fancd2(-/-)) hematopoietic progenitor cell lines can be transformed by transfection with a plasmid containing either the E6 or E7 oncogene of human papillomavirus …
AIM: To demonstrate that Fanconi anemia complementation group D2-deficient (Fancd2(-/-)) hematopoi …
Constitutive role of the Fanconi anemia D2 gene in the replication stress response.
Tian Y, Shen X, Wang R, Klages-Mundt NL, Lynn EJ, Martin SK, Ye Y, Gao M, Chen J, Schlacher K, Li L. Tian Y, et al. J Biol Chem. 2017 Dec 8;292(49):20184-20195. doi: 10.1074/jbc.M117.814780. Epub 2017 Oct 11. J Biol Chem. 2017. PMID: 29021208 Free PMC article.
In response to DNA cross-linking damage, the Fanconi anemia (FA) core complex activates the FA pathway by monoubiquitinating Fanconi anemia complementation group D2 (FANCD2) for the initiation of the nucleolytic processing o …
In response to DNA cross-linking damage, the Fanconi anemia (FA) core complex activates the FA pathway by monoubiquitinating …
Focal Point of Fanconi Anemia Signaling.
Zhan S, Siu J, Wang Z, Yu H, Bezabeh T, Deng Y, Du W, Fei P. Zhan S, et al. Int J Mol Sci. 2021 Nov 30;22(23):12976. doi: 10.3390/ijms222312976. Int J Mol Sci. 2021. PMID: 34884777 Free PMC article. Review.
Among human genetic diseases, Fanconi Anemia (FA) tops all with its largest number of health complications in nearly all human organ systems, suggesting the significant roles played by FA genes in the maintenance of human health. With the accumulated research on FA, …
Among human genetic diseases, Fanconi Anemia (FA) tops all with its largest number of health complications in nearly all human …
641 results